2024-11-192024-11-19https://repositorio.utalca.cl/repositorio/handle/1950/14544A deficiency in omega-3 fatty acids ( to 3 FAs) in the brain has been correlated with cognitive impairment, learning deficiencies, and behavioral changes. In this study, we provided to 3 FAs as a supplement to spontaneously hypertensive rats (SHR+ to 3). Our focus was on examining the impact of dietary supplementation on the physicochemical properties of the brain-cell membranes. Significant increases in to 3 levels in the cerebral cortex of SHR+ to 3 were observed, leading to alterations in brain lipid membranes molecular packing, elasticity, and lipid miscibility, resulting in an augmented phase disparity. Results from synthetic lipid mixtures confirmed the disordering effect introduced by to 3 lipids, showing its consequences on the hydration levels of the monolayers and the organization of the membrane domains. These findings suggest that dietary to 3 FAs influence the organization of brain membranes, providing insight into a potential mechanism for the broad effects of dietary fat on brain health and disease.M/225PIP 2018-0948PIP 2022-0188PIBAA 2022-10142018/22214-6PICT 2018-0881PICT 2019-02331PICT 2021-0766PICT 2020-03526ANR-22-CE43-0017ID2022-140459OB-I00MCIN/AEI/10.13039/5011000110332021-SGR-1410CB06/01/0081