Biological Evaluation of Avocado Residues as a Potential Source of Bioactive Compounds
| datacite.creator | Rojas García, Alejandro | |
| datacite.creator | Fuentes, Eduardo | |
| datacite.creator | de la Luz Cadiz Gurrea, María | |
| datacite.creator | Rodríguez, Lyanne | |
| datacite.creator | del Carmen Villegas Aguilar, María | |
| datacite.creator | Palomo, Iván | |
| datacite.creator | Arraez Román, David | |
| datacite.creator | Segura Carretero, Antonio | |
| datacite.date.issued | 2022 | |
| datacite.identifier | DOI | |
| datacite.identifier.doi | 10.3390/antiox11061049 | |
| datacite.identifier.issn | 2076-3921 | |
| datacite.identifier.orcid | 0000-0003-0099-4108 | |
| datacite.identifier.orcid | 0000-0002-9618-8778 | |
| datacite.identifier.wosid | WOS:000815946300001 | |
| datacite.rights | Acceso abierto | |
| datacite.size | 23 p. | |
| datacite.subject | Avocado by-products | |
| datacite.subject | Phenolic compounds | |
| datacite.subject | HPLC-MS | |
| datacite.subject | Reactive oxygen species | |
| datacite.subject | Enzyme inhibition | |
| datacite.subject | Platelet aggregation | |
| datacite.title | Biological Evaluation of Avocado Residues as a Potential Source of Bioactive Compounds | |
| dc.date.accessioned | 2024-09-02T19:01:15Z | |
| dc.date.available | 2024-09-02T19:01:15Z | |
| dc.description.abstract | Avocado seed and peel are the main by-products from avocado industrialisation, and account for nearly 30% of fruit weight. Although they are usually discarded, their high phenolic content has been deeply associated with several nutritional and functional benefits. Thus, for a comprehensive analytical evaluation of both semi-industrial extracts, various steps have been developed: tentative characterisation and quantification of the phenolic composition using HPLC-ESI-qTOF-MS, determination of TPC and antioxidant activity by Folin-Ciocalteu, FRAP, TEAC and ORAC methods, evaluation of scavenging capacity against different ROS and measurement of the enzymatic inhibitory potential against potentially harmful enzymes. Finally, their bioactive potential was tested in a human platelet model where antiaggregatory activity was measured. Hence, 48 different compounds were identified, where flavonoids and procyanidins were the most representative groups. The higher TPC was found in avocado peel extract (190 ± 3 mg/g), which showed more antioxidant power and more capacity to decrease ROS generation than seed extract (60 ± 2 mg/g). In addition, both extracts showed enzymatic inhibition, especially against hyaluronidase, xanthine oxidase and acetylcholinesterase. Lastly, avocado peel was proven to inhibit platelet aggregation with significant results at 1, 0.75 and 0.5 mg/mL, where the extract showed reducing effects on agonists' expression such as p-selectin or GPIIb/IIIa complex. These results demonstrate that both semi-industrial extracts-above all, avocado peel-have an interesting potential to be exploited as a natural by-product with antioxidant properties with multiple applications for the prevention of different pathologies. | |
| dc.identifier.uri | https://repositorio.utalca.cl/repositorio/handle/1950/13846 | |
| dc.language | Inglés | |
| dc.publisher | MDPI | |
| dc.relation.uri | https://www.mdpi.com/2076-3921/11/6/1049 | |
| dc.source | Antioxidants | |
| oaire.citationIssue | 6 | |
| oaire.citationTitle | Antioxidants | |
| oaire.citationVolume | 11 | |
| oaire.fundingReference | The work was supported by the project P18 TP 3589 (Regional Ministry of Economy, Knowledge, Enterprise and Universities of Andalusia). The author A.R. G. would like to thank the project P18 TP 3589, University of Granada and AGR274 group for the contract (265). The author M.d.C.V. A. would like to thank the Spanish Ministry of Science, Innovation, and Universities for the grant FPU19/01146. The author M.d.l.L.C. G. would like to thank the Regional Ministry of Economy, Knowledge, Enterprise and Universities of Andalusia for the contract for Young Researchers (PAIDI) at the University of Granada. | |
| oaire.licenseCondition | https://creativecommons.org/licenses/by/4.0/ | |
| oaire.licenseCondition.uri | https://creativecommons.org/licenses/by/4.0/ | |
| oaire.resourceType | Artículo de revista | |
| oaire.version | Versión publicada | |
| utalca.catalogador | MPE | |
| utalca.facultad | Universidad de Talca (Chile). Facultad de Ciencias de la Salud. Centro de Investigación de Trombosis | |
| utalca.index | Artículo indexado en Web of Science | |
| utalca.index | Artículo indexado en Scopus | |
| utalca.informaciondegenero | Hombre y Mujer | |
| utalca.ods | Salud y bienestar |
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