Inhibition of platelet aggregation by extracts and compounds from the leaves of Chilean bean landraces (Phaseolus vulgaris L.)

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datacite.creatorFuentes, Eduardo
datacite.creatorRodríguez, Lyanne
datacite.creatorMendez, Diego
datacite.creatorAlarcón-Espósito, Jazmín
datacite.creatorNina, Nelida
datacite.creatorBurgos-Edwards, Alberto
datacite.creatorCarrasco, Basilio
datacite.creatorPalomo González, Iván
datacite.creatorSchmeda-Hirschmann, Guillermo
datacite.date.issued2023
datacite.identifierDOI
datacite.identifier.doi10.1016/j.jff.2022.105388
datacite.identifier.issn1756-4646
datacite.identifier.orcid0000-0002-9618-877811
datacite.identifier.orcid0000-0001-7991-0303
datacite.identifier.orcid0000-0002-8389-9239
datacite.identifier.orcid0000-0003-0099-4108
datacite.identifier.wosidWOS:000918664500001
datacite.rightsAcceso abierto
datacite.size9 p.
datacite.subjectPhaseolus vulgaris
datacite.subjectChilean bean landraces
datacite.subjectAnti-platelet aggregation
datacite.subjectRutin
datacite.subjectKaempferol 3-glucoside
datacite.subjectCaffeoyl malic acid
datacite.titleInhibition of platelet aggregation by extracts and compounds from the leaves of Chilean bean landraces (Phaseolus vulgaris L.)
dc.date.accessioned2024-11-07T19:43:50Z
dc.date.available2024-11-07T19:43:50Z
dc.description.abstractLeaf extracts from Chilean bean landraces were assessed for antiplatelet activity using different assays in vitro. Lyophilized MeOH:H2O 7:3 (v/v) and EtOH:H2O 7:3 (v/v) leaf extracts from the Chilean landraces Coscorron, Frutilla, Magnum, Sapito and Tortola were compared for platelet aggregation effect by turbidimetry and flow cytometry. The HPLC-DAD study allowed the identification of caffeoyl malic acid, derivatives of quercetin and kaempferol. The results showed that the EtOH:H2O 7:3 extracts have higher antiplatelet capacity, with better effects for the Frutilla and Sapito landraces (IC50 0.38 ± 0.05 and 0.16 ± 0.08 mg/mL, respectively). The Sapito extract inhibited P-selectin expression, CD63 secretion, and concentration-dependent GPIIb/IIIa activation. The activity was associated with the main phenolics content, including rutin, caffeoyl malic acid and kaempferol 3-O-glucoside. The findings add evidence for the potential of bean leaves as greens, affording naturally occurring compounds with health promoting properties, including inhibition of platelet aggregation in vitro.
dc.identifier.folio1210076
dc.identifier.urihttps://repositorio.utalca.cl/repositorio/handle/1950/14389
dc.languageInglés
dc.publisherElsevier
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S1756464622004583?via%3Dihub
dc.sourceJournal of Functional Foods
oaire.citationTitleJournal of Functional Foods
oaire.citationVolume100
oaire.fundingReferenceThis research was funded by Centro de Estudios en Alimentos Procesados-CEAP, ANID, Programa Regional R20F0001, Talca, Chile and FONDECYT 1210076.
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo de Revista
oaire.versionVersión publicada
utalca.catalogadorMPE
utalca.facultadUniversidad de Talca (Chile). Facultad de Ciencias de la Salud. Centro de Investigación de Trombosis.
utalca.facultadUniversidad de Talca (Chile). Instituto de Química de Recursos Naturales.
utalca.idcargampe07112024
utalca.indexArtículo indexado en Web of Science
utalca.indexArtículo indexado en Scopus
utalca.informaciondegeneroHombre y Mujer
utalca.odsSalud y bienestar
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