Understanding the effects of omega-3 fatty acid supplementation on the physical properties of brain lipid membranes

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datacite.creatorLongarzo, María L.
datacite.creatorVázquez, Romina F.
datacite.creatorBellini, María J.
datacite.creatorZamora, Ricardo A.
datacite.creatorRedondo Morata, Lorena
datacite.creatorGiannotti, Marina I.
datacite.creatorOliveira Jr., Osvaldo N.
datacite.creatorFanani, María L.
datacite.creatorMate, Sabina M.
datacite.date.issued2024
datacite.identifierDOI
datacite.identifier.doi10.1016/j.isci.2024.110362
datacite.identifier.issn2589-0042
datacite.identifier.orcid0000-0002-7757-1640
datacite.identifier.orcid0000-0002-0815-742X
datacite.identifier.orcid0000-0002-8779-3503
datacite.identifier.wosidWOS:001267043800001
datacite.rightsAcceso abierto
datacite.subjectMolecular packing
datacite.subjectBehavior
datacite.titleUnderstanding the effects of omega-3 fatty acid supplementation on the physical properties of brain lipid membranes
dc.date.accessioned2024-11-19T13:27:15Z
dc.date.available2024-11-19T13:27:15Z
dc.description.abstractA deficiency in omega-3 fatty acids ( to 3 FAs) in the brain has been correlated with cognitive impairment, learning deficiencies, and behavioral changes. In this study, we provided to 3 FAs as a supplement to spontaneously hypertensive rats (SHR+ to 3). Our focus was on examining the impact of dietary supplementation on the physicochemical properties of the brain-cell membranes. Significant increases in to 3 levels in the cerebral cortex of SHR+ to 3 were observed, leading to alterations in brain lipid membranes molecular packing, elasticity, and lipid miscibility, resulting in an augmented phase disparity. Results from synthetic lipid mixtures confirmed the disordering effect introduced by to 3 lipids, showing its consequences on the hydration levels of the monolayers and the organization of the membrane domains. These findings suggest that dietary to 3 FAs influence the organization of brain membranes, providing insight into a potential mechanism for the broad effects of dietary fat on brain health and disease.
dc.description.pages16 p.
dc.identifier.folioM/225
dc.identifier.folioPIP 2018-0948
dc.identifier.folioPIP 2022-0188
dc.identifier.folioPIBAA 2022-1014
dc.identifier.folio2018/22214-6
dc.identifier.folioPICT 2018-0881
dc.identifier.folioPICT 2019-02331
dc.identifier.folioPICT 2021-0766
dc.identifier.folioPICT 2020-03526
dc.identifier.folioANR-22-CE43-0017
dc.identifier.folioID2022-140459OB-I00
dc.identifier.folioMCIN/AEI/10.13039/501100011033
dc.identifier.folio2021-SGR-1410
dc.identifier.folioCB06/01/0081
dc.identifier.urihttps://repositorio.utalca.cl/repositorio/handle/1950/14544
dc.languageInglés
dc.publisherCell Press
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2589004224015876
dc.sourceiScience
oaire.citationTitleiScience
oaire.fundingReferenceFinancial support for this work has been provided by the UNLP (M/225) , CONICET (PIP 2018-0948 and PIP 2022-0188 to S.M.M, and PIBAA 2022-1014 to R.F.V) , CNPq and FAPESP (2018/22214-6) to O.N.O.Jr., and ANPCyT (PICT 2018-0881 to S.M.M., PICT 2019-02331 and PICT 2021-0766 to M.L.F., and PICT 2020-03526 to R.F.V.) . R.F.V. also thanks SeCyT-UNLP for travel funds. L.R.-M. acknowledges financial support from "Tremplin International"Inserm 2022 (project NanExo) and the support of the French Agence Nationale de la Recherche (ANR) , under grant ANR-22-CE43-0017 (project MOWGLY) . M.I.G. acknowledges financial support from Spanish Ministry of Science and Innovation (project PID2022-140459OB-I00 funded by MCIN/AEI/10.13039/501100011033/and by FEDER Away of making Europe) , Agency for Management of University and Research Grants (2021-SGR-1410 project) , and CIBER (Consorcio Centro de Investigacion Biomedica en Red, CB06/01/0081) , Instituto de Salud Carlos III, Ministerio de Ciencia e Innovacion.
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo de Revista
oaire.versionVersión Publicada
utalca.catalogadorPAG
utalca.facultadUniversidad de Talca (Chile). Vicerretoría Académica. Instituto de Investigación Interdisciplinario.
utalca.facultadUniversidad de Talca (Chile). Facultad de Ingeniería. Centro de Bioinformática Simulación y Modelado.
utalca.idcargapag191124
utalca.indexArtículo indexado en Web of Science
utalca.indexArtículo indexado en Scopus
utalca.informaciondegeneroHombre y Mujer
utalca.odsSalud y bienestar
utalca.odsIndustria, innovación e infraestructura
utalca.odsProducción y consumo responsables
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